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Nov 18, 2009

Smoking May Now Be Considered An Established Risk Factor For ALS

While previous studies have indicated a "probable" connection between smoking and ALS, a new study published in the Nov. 17, 2009 issue of Neurology®, the medical journal of the American Academy of Neurology, states that smoking may now be considered an "established" risk factor for Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease.

The findings come from Baystate Medical Center neurologist Dr. Carmel Armon, an ALS researcher and neuroepidemiologist, who came to this conclusion using evidence-based methods to perform a rigorous analysis of studies examining the link between smoking and developing ALS -- a fatal neurodegenerative disease affecting the motor nerves and the voluntary muscles.

"Application of evidence-based methods separates better-designed studies from studies with limitations that may not be relied on. The better-designed studies show consistently that smoking increases the risk of developing ALS, with some findings suggesting that smoking may be implicated directly in causing the disease," said Dr. Armon, a professor of neurology at Tufts University School of Medicine and chief of neurology at Baystate Medical Center in Springfield. He is also a fellow of the American Academy of Neurology.

According to Dr. Armon, identifying smoking as an established risk factor for ALS has three implications.

"First and foremost the findings provide a link between the environment and the occurrence of ALS, where none had been previously identified with this level of certainty," said Dr. Armon.

"Additional implications are that since smoking has no redeeming features, avoidance of smoking may reduce the occurrence of ALS in the future, and since some of the mechanisms by which smoking causes other diseases in humans are understood fairly well, recognizing its role in the occurrence of ALS may help pinpoint the biological processes that initiate the disease," added the researcher.

The Baystate Medical Center neurologist noted that focusing on processes at initiation of sporadic ALS, and close to it, may provide new avenues to treatment to stop its progression.

"This has been realized in some animal models of familial ALS, but not in humans. The hope that these concepts may apply to sporadic disease and change its outlook in the future is supported by establishing the association of smoking with ALS occurrence," concluded Dr. Armon.

ALS takes the lives of half of those affected within three years of onset of weakness, with less than five percent surviving more than 10 years. Some 90-95 percent of cases appear to occur at random ("sporadic cases'), with 5-10 percent of cases having an affected blood relative ("familial cases"). An altered gene, several of which have been identified, is implicated in causing familial ALS. Prior to this report, no external factors have been implicated with this level of confidence as contributing to the occurrence of sporadic ALS.

6 comments:

buy viagra cheap online said...

Smoking is one of the addiction which can lead to death also it reduces the life span. One in three smokers who do not stop the smoking will eventually die. Some smokers will die in their 40s and others will die later. On average, they will die 10 to 15 years earlier than they would have died from other causes. Some people try to stop smoking but they failed because they are addicted to it.

order kamagra online said...

Smoking is bad for our health.... it greatly increases risk of health disease.So i wish that more and more people read this post and understand the health risk by smoking...

Regards
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atmos said...

Smoking is very dangerous addiction which makes our body wholly dependent on nicotine and so it becomes hard to quit smoking ..But ultimately it means to push life towards death..

Atmos said...

Smoking is the an very hell addiction which leads to only destruction and it only reduces years to life and nothing else. So to save life smoking sholud be given up either by using a portable vaporizer or an e-cig.

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